Key result
Local thrombolysis with interventional therapy and sequential intravenous thrombolysis successfully resolved pulmonary thromboembolism in a patient with severe pulmonary tuberculosis.
Why the study?
Reports of pulmonary thromboembolism with tuberculosis are rare worldwide, and it remains unclear which tuberculosis patients are more susceptible to pulmonary thromboembolism.
Case Report (n=1)
No
Severe pulmonary tuberculosis should be considered a risk factor for thromboembolism, and interventional thrombolysis is an effective and safe treatment option for medium-high risk PTE in these patients.
Pulmonary thromboembolism (PTE) is an acute and severe disease with high mortality, which is prone to be misdiagnosed or ignored especially when complicated with tuberculosis (TB). Even though TB has been considered as a risk factor for PTE, there is rare report of TB with PTE worldwide. Which TB patients are more susceptible to PTE is still not clear. Here, we described a case report of PTE with pulmonary TB in a 28-year-old man, who had no risk factors for pulmonary thrombosis at admission and developed a medium-high PTE after initiating anti-TB therapy. After local thrombolysis with interventional therapy and sequential intravenous thrombolysis, combined with long-term anticoagulation, the PTE of the patient disappeared. At follow-up of 4 months, the patient was re-examined with chest enhanced CT and no obvious emboli was found. We emphasize that acute or severe TB infection should be included in the thromboembolism risk assessment and prophylactic use of anticoagulants may be considered even if there are no other obvious risk factors. Interventional therapy is a good option for thrombolysis treatment if hospital condition permits.
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Huang et al. (2019) conducted a case report in Severe pulmonary tuberculosis complicated with pulmonary thromboembolism (n=1). Local thrombolysis with interventional therapy was evaluated on Resolution of pulmonary thromboembolism. Local thrombolysis with interventional therapy and sequential intravenous thrombolysis successfully resolved pulmonary thromboembolism in a patient with severe pulmonary tuberculosis.
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