Key result
Reducing peripheral isoflurane fails to change minimum alveolar anesthetic concentration compared to baseline.
Why the study?
Does peripheral isoflurane concentration influence the minimum alveolar anesthetic concentration required to suppress movement in response to noxious stimuli in dogs?
Population
6 isoflurane-anesthetized mongrel dogs
Comparison
Diminished isoflurane concentration at the site… vs Normal blood flow and matched end-tidal…
Design
Preclinical
Authors
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Peripheral isoflurane does not alter MAC in dogs; leaves open central mechanisms as primary determinants for clinical translation.
Does peripheral isoflurane concentration influence the minimum alveolar anesthetic concentration required to suppress movement in response to noxious stimuli in dogs?
Absolute Event Rate: 1.2% vs 1.3%
p-value: p=> 0.05
The peripheral effects of isoflurane do not influence the minimum alveolar anesthetic concentration required to suppress movement in response to noxious stimuli.
Antognini et al. (1995) studied Isoflurane anesthesia (n=6). Lower body bypass to alter peripheral isoflurane concentration vs. Baseline normal blood flow was evaluated on Minimum alveolar anesthetic concentration (MAC) (p=> 0.05). Reducing peripheral isoflurane concentration to 0.2% in the lower body did not significantly change the minimum alveolar anesthetic concentration compared to baseline (1.2% vs 1.3%; P>0.05).
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