Why the study?
Does isoflurane anesthesia alter the recirculatory pharmacokinetics of physiologic markers in coonhounds?
Does isoflurane anesthesia alter the recirculatory pharmacokinetics of physiologic markers in coonhounds?
Isoflurane anesthesia alters early drug concentration history by changing both cardiac output and its peripheral distribution.
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Should not change clinical practice; leaves open whether isoflurane alters human drug kinetics similarly.
Avram et al. (2000) studied this question.
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