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May 21, 2022Journal of Food Biochemistry

Naringenin induces endoplasmic reticulum stress‐mediated cell apoptosis and autophagy in human oral squamous cell carcinoma cells

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Authors

JLJu‐Fang LiuChina Medical UniversityTCTsung‐Ming ChangPCPo‐Han ChenYale University

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Overview

In vitro study demonstrates naringenin-induced apoptosis and autophagy in oral cancer cells, suggesting its potential as a natural therapeutic.

Key Points

  • To evaluate the antitumor effects and underlying molecular mechanisms of the natural flavonoid naringenin in human oral squamous cell carcinoma (OSCC) cells.
  • Treated human oral squamous cell carcinoma (OSCC) cells with the natural flavonoid naringenin in vitro.
  • Evaluated markers of cell viability, apoptotic signaling cascades, autophagy regulation, reactive oxygen species (ROS) production, and endoplasmic reticulum (ER) stress.
  • Naringenin induced intracellular reactive oxygen species (ROS) production and provoked ER stress accompanied by aberrant intracellular Ca2+ release.
  • Treatment triggered apoptotic programmed cell death via caspase-cascade activation and mitochondrial dysfunction in OSCC cells.
  • Naringenin altered autophagy from a pro-survival mechanism into a pro-death pathway, significantly reducing oral cancer cell viability.

Cite This Study

Liu et al. (2022) studied this question.

synapsesocial.com/papers/6aa45dae2689ede29b20cc24https://doi.org/10.1111/jfbc.14221
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