Key result
Phylogenetic analysis of 926 HEV-3 sequences estimated a substitution rate of 1.01×10-2 substitutions/site/year and suggested multiple introductions of the virus into Argentina.
Why the study?
Few studies have examined the evolutionary history of the hepatitis E virus, leaving the origin and routes of dispersion of HEV-3 in Argentina unclear.
Effect estimate: 1.01×10-2 substitutions/site/y (95% CI 9.3×10-3-1.09×10-2)
This study provides the first evolutionary inference of HEV-3 including Argentinian strains, suggesting multiple introductions into the country, likely from Europe and Japan.
Authors
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Initial HEV-3 phylogenetic data from Argentina suggest multiple introductions; leaves open timing and sources pending larger regional genomic studies.
Pisano et al. (2021) studied Hepatitis E virus genotype 3 (n=926). Phylogenetic and phylogeographic analysis was evaluated on Substitution rate (1.01×10-2 substitutions/site/y, 95% CI 9.3×10-3-1.09×10-2). Phylogenetic analysis of 926 HEV-3 sequences estimated a substitution rate of 1.01×10-2 substitutions/site/year and suggested multiple introductions of the virus into Argentina.
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