Key result
Combined mitral and aortic valve replacement restores resting hemodynamics but LV exercise response remains abnormal.
Why the study?
Does combined prosthetic replacement of the mitral and aortic valves improve resting and exercise hemodynamics in patients with severe aortic and mitral valve disease?
Population
12 patients with severe aortic and mitral valve disease
Comparison
Replacement of both aortic and mitral valves… vs Preoperative baseline
Design
Case_series
Authors
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Residual exertional LV dysfunction after dual valve replacement warrants cautious expectations; leaves open mechanisms of incomplete recovery for prospective study.
Observational (n=12)
Does combined prosthetic replacement of the mitral and aortic valves improve resting and exercise hemodynamics in patients with severe aortic and mitral valve disease?
Combined aortic and mitral valve replacement normalizes resting hemodynamics, but residual myocardial impairment limits normal left ventricular response to exercise.
Mason et al. (1967) conducted an observational in Severe aortic and mitral valve disease (n=12). Combined prosthetic replacement of the mitral and aortic valves was evaluated on Resting and exercise hemodynamic parameters. Combined prosthetic replacement of the mitral and aortic valves restored resting hemodynamics, but left ventricular response to exercise remained abnormal in all assessed patients.
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