Key result
In patients with STEMI and preserved ejection fraction, PICP concentrations significantly reduced over 1 year and correlated with visceral obesity index, age, and left ventricular ejection fraction.
Why the study?
The dynamics of fibrosis markers PICP and PIIINP in patients with STEMI and preserved myocardial contractility needed to be identified.
Observational (n=86)
In patients with STEMI and preserved LVEF, fibrosis markers PICP and PIIINP correlate with visceral obesity, age, and LVEF over a 1-year follow-up.
PICP decline post-STEMI with preserved LVEF was associated with visceral obesity; leaves open whether fibrosis markers guide risk stratification or interventions.
Purpose. To identify the peculiarities of the dynamics of fibrosis markers of C-terminal procollagen propeptide type I (PICP) and N-terminal collagen propeptide type III (PIIINP) in patients with ST segment elevation myocardial infarction (STEMI) and preserved myocardial contractility. Material and methods. 86 patients with STEMI and preserved left ventricular ejection fraction were examined. In addition to the standard laboratory and instrumental examinations, all the patients underwent the estimation of the concentrations of C-terminal procollagen propeptide type I (PICP) and N-terminal collagen propeptide type III (PIIINP) by enzyme-linked immunoassay using BCM Diagnostics laboratory kits (USA) on the 1st and the 12th days of disease and 1 year later. Results. The concentration of PICP was significantly reduced in all groups during the entire observation period. Significant correlations were found between PICP and visceral obesity index, age and left ventricular ejection fraction. A relationship was found between PIIINP and an increased visceral obesity index.
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Осокина et al. (2020) conducted an observational in ST segment elevation myocardial infarction (STEMI) with preserved left ventricular ejection fraction (n=86). Visceral obesity index was evaluated on Dynamics of fibrosis markers (PICP and PIIINP). In patients with STEMI and preserved ejection fraction, PICP concentrations significantly reduced over 1 year and correlated with visceral obesity index, age, and left ventricular ejection fraction.
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