Key result
Higher levels of surgical risk were significantly correlated with greater postoperative increases in high-sensitivity cardiac troponin levels (r = 0.643, p < 0.001).
Why the study?
Myocardial injury after non-cardiac surgery (MINS) is directly linked to 30-day mortality, and hs-troponin is the most sensitive biomarker for detecting MINS, prompting analysis of the relationship between surgical risk levels and hs-troponin changes.
Cross-Sectional (n=75)
No
Effect estimate: r = 0.643
p-value: p=<0.001
Changes in high-sensitivity cardiac troponin levels before and 24 hours after non-cardiac surgery significantly correlate with the level of surgical risk.
May support troponin for perioperative risk assessment; hypothesis-generating and requires prospective validation before practice change.
Kontext: Pokozen myokardu po nekardilnm chirurgickm vkonu (myocardial injury after non-cardiac surgery, MINS) pedstavuje zvan problm pmo souvisejc s mortalitou do 30 dn po vkonu. V diagnostice pokozen myokardu se pednostn pouvaj hodnoty vysoce senzitivnho srdenho troponinu (high-sensitivity cardiac troponin, hs troponin), protoe se v souasnosti jedn o nejcitlivj a nejspecifitj srden biomarker vhodn pro zjiovn MINS. Clem tto studie je analyzovat vztah mezi zmnami v hodnotch hs troponinu a riziky spojenmi s chirurgickm vkonem u pacient podstupujcch nekardiln chirurgick vkony, kter by ukazovaly na pokozen myokardu. Metoda: Nae studie je analytickou observan prezovou studi, do n byli zaazovni vichni pacienti podstupujc nekardiln chirurgick vkon ve fakultn nemocnici Airlangga University Hospital. Krevn vzorky byly odebrny metodou nhodnho vzorku (consecutive sampling) a hodnoty hs troponinu se stanovovaly ped operac a 24 hodin po n. Mra operanho rizika se hodnotila pomoc kritri doporuench postup ESAIC-ESC 2022. Statistick analza se provdla s pouitm Spearmanova korelanho koeficientu. Vsledky: Do studie bylo zaazeno 75 pacient, 39 mu a 36 en, ve vku s medinem 54 let. Vsledky prokzaly statisticky vznamnou korelaci mezi hodnotami hs troponinu a mrou operanho rizika, a to jak pedoperanmi hodnotami, tak i pooperanmi a jejich zmnami. Medin hodnoty (mezikvartilov rozpt) hs troponinu pi nzkm operanm riziku ped operac vs. po operaci inil 1,2 ng/l (0,0), resp. 1,2 ng/l (0,0), s medinem rozdlu 0,0 ng/l (0,0); p < 0,001. Medin hodnoty hs troponinu pi stedn vysokm operanm riziku ped operac vs. po operaci byl 1,2 ng/l (0,0) vs. 1,2 ng/l (0,0), s medinem rozdlu 0,0 ng/l (1,6); p < 0,001. Medin hodnoty hs troponinu pi vysokm operanm riziku ped operac vs. po operaci byl 1,7 ng/l (18,8) vs. 11,9 ng/l (27,6); medin rozdlu inil 5,3 ng/l (11,4); p < 0,001. Zvr: Byla nalezena statisticky vznamn korelace mezi zmnami hodnot hs troponinu a mrou operanho rizika a ptomnost komplikac.
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Putri et al. (2024) conducted a cross-sectional in Non-cardiac surgery (n=75). Level of surgical risk vs. Low surgical risk was evaluated on Correlation between surgical risk level and change in high-sensitivity troponin levels (r = 0.643, p=<0.001). Higher levels of surgical risk were significantly correlated with greater postoperative increases in high-sensitivity cardiac troponin levels (r = 0.643, p < 0.001).
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