Why the study?
Studies assessing cardiac biomarkers as prognostic predictors after PCI in chronic ischemic heart disease have shown contradictory results, and hs-TnT offers a newer, more accurate assessment.
Does positive high-sensitive troponin T post-PCI predict major adverse cardiovascular events at 1 year in patients with stable angina pectoris undergoing elective PCI?
Cohort (n=100)
Yes
Does positive high-sensitive troponin T post-PCI predict major adverse cardiovascular events at 1 year in patients with stable angina pectoris undergoing elective PCI?
Odds Ratio: 3.36 (95% CI 1.09–10.33)
Absolute Event Rate: 36.1% vs 15.6%
p-value: p=0.034
Elevated high-sensitive troponin T measured 3-4 hours after successful elective PCI in patients with stable angina is associated with a higher risk of MACE at 1 year.
CĂl: NÄkolik studiĂ zkoumalo rĹŻznĂŠ srdeÄnĂ biomarkery jako prediktory prognĂłzy po perkutĂĄnnĂ koronĂĄrnĂ intervenci (PCI) u pacientĹŻ s chronickou ischemickou chorobou srdeÄnĂ; vĂ˝sledky tÄchto studiĂ jsou vĹĄak rozporuplnĂŠ. StanovovĂĄnĂ troponinu T vysoce citlivou metodou (high-sensitive troponin T, hs-TnT) pĹedstavuje novou a pĹesnÄjĹĄĂ moĹžnost. CĂlem tĂŠto studie bylo zjistit, zda mohou hodnoty hs-TnT slouĹžit jako prediktor zĂĄvaĹžnĂ˝ch kardiovaskulĂĄrnĂch pĹĂhod (major adverse cardiovascular events, MACE) v prvnĂm roce po ĂşspÄĹĄnĂŠ plĂĄnovanĂŠ PCI u pacientĹŻ se stabilnĂ anginou pectoris (SAP). MateriĂĄl a metody: Do studie bylo zaĹazeno 100 pacientĹŻ s diagnĂłzou SAP a ĂşspÄĹĄnÄ provedenou plĂĄnovanou PCI. Ze studie byli vylouÄeni nemocnĂ se zvýťenĂ˝mi hodnotami troponinu I (> 0,1 ng/ml) pĹed vĂ˝konem. Hodnoty hs-TnT se stanovovaly pĹed vĂ˝konem a v rozmezĂch 3-4 hodin (ÄasnĂŠ obdobĂ) a 12-24 hodin (pozdnĂ obdobĂ) po vĂ˝konu, pĹiÄemĹž za pozitivnĂ byla povaĹžovĂĄna hodnota hs-TnT > 14 pg/ml. Byla rovnÄĹž zaznamenĂĄvĂĄna incidence MACE v prvnĂm roce. VĂ˝sledky: Hodnoty hs-TnT byly pozitivnĂ u 36 % pacientĹŻ v prvnĂm obdobĂ a u 54 % pacientĹŻ v pozdnĂm obdobĂ. Incidence MACE v prvnĂm roce byla vĂ˝znamnÄ vyĹĄĹĄĂ u pacientĹŻ s pozitivnĂmi hodnotami hs-TnT v ÄasnĂŠm, ne vĹĄak v pozdnĂm obdobĂ (36,1 % vs. 15,6 %; p = 0,026); logistickĂĄ regresnĂ analĂ˝za prokĂĄzala pomÄr ĹĄancĂ ve výťi 3,36. ZĂĄvÄr: Hodnoty hs-TnT namÄĹenĂŠ 3-4 hodiny po ĂşspÄĹĄnĂŠ elektivnĂ PCI u pacientĹŻ se SAP mohou predikovat incidenci MACE v prvnĂm roce. Tyto vĂ˝sledky musĂ nicmĂŠnÄ potvrdit vÄtĹĄĂ studie.
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Aktaş et al. (2021) conducted a cohort in Stable angina pectoris (n=100). Positive high sensitive troponin T (>14 pg/mL) at 3-4 hours post-PCI vs. Negative high sensitive troponin T (≤14 pg/mL) at 3-4 hours post-PCI was evaluated on Major adverse cardiovascular events (MACE) at 1 year (OR 3.36, 95% CI 1.09-10.33, p=0.034).
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