What question did this study set out to answer?

To evaluate the prognostic importance of cardiac troponin I (cTnI) elevation following percutaneous coronary intervention in patients with acute coronary syndrome compared to stable angina pectoris.

January 1, 2008Scandinavian Cardiovascular Journal

Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris

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Why the study?

Does cardiac troponin I (cTnI) elevation after PCI predict adverse outcomes in patients with acute coronary syndrome compared to those with stable angina pectoris?

Population

432 patients undergoing percutaneous coronary intervention, comprising 238 patients presenting with acute…

Comparison

Cardiac troponin I elevation after percutaneous… vs Unchanged cTnI status after PCI

Design

Cohort

Follow-up

one year

Authors

JGJørgen GravningHeart Failure & Transplant TUThor UelandHeart Failure & Transplant LMLars MørkridOslo University Hospital

Discussion

Member takes

Implication

May stratify 1-year risk in ACS but not SAP post-PCI; hypothesis-generating and should not yet change practice.

Key Points

To evaluate the prognostic importance of cardiac troponin I (cTnI) elevation following percutaneous coronary intervention in patients with acute coronary syndrome compared to stable angina pectoris.
Enrolled 238 patients presenting with acute coronary syndrome (ACS) and 194 patients with stable angina pectoris (SAP) undergoing percutaneous coronary intervention (PCI).
Monitored patients over one year of follow-up for a composite end point consisting of death or hospitalization due to non-fatal myocardial infarction, repeated revascularization, or unstable angina.
cTnI elevation post-PCI occurred more frequently in ACS than SAP patients, and ACS patients with elevated cTnI had significantly higher event rates than those with unchanged post-PCI cTnI.
Event rates were significantly higher in ACS patients than SAP patients across comparable levels of post-PCI cTnI elevation.
In patients with SAP, overall event rates were lower, and no significant difference in clinical events was observed between those with or without post-PCI cTnI elevation.

Structured PICO

Does cardiac troponin I (cTnI) elevation after PCI predict adverse outcomes in patients with acute coronary syndrome compared to those with stable angina pectoris?

Population

432 patients undergoing percutaneous coronary intervention (PCI), comprising 238 patients presenting with acute coronary syndrome (ACS) and 194 patients with stable angina pectoris (SAP).

Intervention

Cardiac troponin I (cTnI) elevation after percutaneous coronary intervention (PCI)

Comparator

Unchanged cTnI status after PCI

Outcome

Composite end point of death or hospitalization due to non-fatal myocardial infarction, repeated revascularization or unstable angina during one year of follow-upcomposite

Post-PCI troponin I elevation is a prognostic marker for adverse events at one year in patients with acute coronary syndrome, but not in those with stable angina.

Cite This Study

Gravning et al. (2008) studied this question.

synapsesocial.com/papers/6a72ebc7c94dd74093748a44 https://doi.org/10.1080/14017430801932824

Topics

Women and heart disease

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Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider