Key result
Atrial pacing increases plasma ANP concentrations in conscious rabbits, correlating directly with achieved heart rate.
Why the study?
Does atrial pacing increase plasma ANP concentrations in conscious rabbits?
Does atrial pacing increase plasma ANP concentrations in conscious rabbits?
Atrial pacing at high rates increases plasma ANP concentrations in a rate-dependent manner in conscious rabbits.
Rate-dependent ANP release with atrial pacing in rabbits; leaves open translation to human tachyarrhythmias.
The effect of increases in heart rate on plasma atrial natriuretic peptide (ANP) concentrations was investigated in conscious rabbits. Plasma ANP concentrations were significantly increased following abrupt increases in heart rate produced by atrial pacing at 400 beats/min. Pacing at 300 beats/min resulted in smaller increases in plasma ANP concentration. Stepwise increases in heart rate produced by atrial pacing at 250, 300, 350 and 400 beats/min resulted in increases in plasma ANP concentrations at 400 beats/min only. The increase in plasma ANP concentration during atrial pacing correlated significantly with the increase in heart rate achieved.
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Morris et al. (1987) studied this question. Atrial pacing vs. Baseline or lower heart rates was evaluated on Plasma atrial natriuretic peptide (ANP) concentrations. Atrial pacing significantly increased plasma atrial natriuretic peptide concentrations in conscious rabbits, with the increase correlating significantly with the achieved heart rate.
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