Atrial pacing stimulates secretion of atrial natriuretic polypeptide without elevation of atrial pressure in awake dogs with experimental complete atrioventricular block.
Why the study?
Does rapid atrial pacing stimulate ANP secretion without elevating atrial pressure in dogs with complete AV block?
Population
9 awake dogs.
Comparison
Rapid atrial pacing. vs Baseline state (before pacing).
Design
Preclinical
Authors
Discussion
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Implication
Suggests autonomic control of ANP release independent of pressure in AV block models; leaves open relevance to human tachyarrhythmias.
Key Points
- To determine whether rapid atrial pacing stimulates the secretion of atrial natriuretic polypeptide independently of increases in atrial pressure.
- Evaluated awake dogs with normal sinus rhythm (N=4) and complete atrioventricular block induced by surgical heat cauterization of the His bundle (N=5).
- Delivered rapid atrial pacing alone and simultaneously with ventricular pacing while recording left and right atrial pressures and coronary sinus plasma hormone concentrations.
- Tested hormone secretion responses before and after the infusion of autonomic blocking agents.
- In normal sinus rhythm dogs, pacing elevated right atrial pressure (0.2 ± 0.1 to 3.9 ± 0.8 mm Hg), left atrial pressure (0.2 ± 0.1 to 8.6 ± 2.8 mm Hg), and coronary sinus atrial natriuretic polypeptide from 405 ± 99 to 849 ± 199 pg/ml (p < 0.01).
- In dogs with complete atrioventricular block, rapid atrial pacing increased atrial natriuretic polypeptide from 730 ± 82 to 1,137 ± 35 pg/ml (p < 0.01) and concurrent pacing increased levels from 480 ± 172 to 626 ± 223 pg/ml (p < 0.05) without altering atrial pressures.
- Infusion of autonomic blocking agents suppressed the rapid pacing-induced secretion of atrial natriuretic polypeptide.
Structured PICO
Does rapid atrial pacing stimulate ANP secretion without elevating atrial pressure in dogs with complete AV block?
P
Population
9 awake dogs (4 with normal sinus rhythm, 5 with surgically induced complete atrioventricular block by heat cauterization of His' bundle).
I
Intervention
Rapid atrial pacing.
C
Comparator
Baseline state (before pacing).
O
Outcome
Plasma atrial natriuretic polypeptide (ANP) level obtained from the coronary sinus.surrogate
Rapid atrial pacing stimulates ANP secretion independently of atrial pressure elevation, an effect that is mediated by the autonomic nervous system.
Cite This Study
Nishimura et al. (1990) studied this question.