Why the study?
Does cardiac denervation alter the hemodynamic, hormonal, and renal responses to rapid atrial pacing in dogs?
Population
17 dogs (8 control and 9 cardiac-denervated) under chloralose anesthesia
Comparison
Rapid atrial pacing at approximately 250 ppm for… vs Control dogs with intact cardiac nerves
Design
Preclinical
Follow-up
60 min
Authors
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Denervation disrupts diuretic and hormonal responses to pacing in dogs; hypothesis-generating for neural modulation in human volume regulation.
Does cardiac denervation alter the hemodynamic, hormonal, and renal responses to rapid atrial pacing in dogs?
Cardiac nerves are required for the diuretic response to rapid atrial pacing via inhibition of renin and vasopressin, whereas ANP secretion is independent of cardiac innervation.
Williams et al. (1989) studied this question.
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