Blunted Natriuretic Response to Endogenous Atrial Natriuretic Peptide During Rapid Cardiac Pacing in Anaesthetized Dogs

View Full Paper

Ask AI

Bookmark

Population

Anaesthetized closed-chest dogs

Comparison

Severe rapid cardiac pacing via the right… vs Moderate rapid cardiac pacing via the right…

Design

Preclinical

Follow-up

180 min

Authors

Discussion

Indicates renal ANP resistance during severe pacing; hypothesis-generating for perfusion effects in heart failure models.

Population

Anaesthetized closed-chest dogs

Intervention

Severe rapid cardiac pacing via the right ventricle at 250 b.p.m. for 180 min

Comparator

Moderate rapid cardiac pacing via the right ventricle at 200 b.p.m. for 180 min

Outcome

Changes in plasma ANP, renal function (urine volume, urinary and fractional excretion of sodium), and haemodynamicssurrogate

Severe rapid cardiac pacing blunts the renal natriuretic response to endogenous ANP, potentially due to decreased renal perfusion pressure.

Yoneda et al. (1998) studied this question.

View Full Paper

Ask AI

Bookmark