Key result
Prompt discontinuation and benzodiazepines resolve serotonin syndrome linked to tramadol, bupropion, and paroxetine within 24 hours.
Why the study?
Serotonin syndrome is seen more frequently, can rapidly progress to a life-threatening state, and presents variably, requiring prompt recognition and treatment to avoid complications.
Case Report (n=1)
Prompt recognition and treatment of serotonin syndrome in the emergency department is imperative to avoid life-threatening complications.
Early recognition may avert serotonin syndrome complications in the ED; case report leaves open need for prospective data.
With the widespread use of serotonergic agents including many antidepressants, antiemetics, illicit drugs, and even some herbal supplements, serotonin syndrome is a condition seen more frequently. It can appear abruptly and, if untreated, can progress to a life-threatening state. Prompt recognition and treatment is imperative to avoid complications. The presentation is variable and can be confused with other conditions. The authors present a case of serotonin syndrome that was recognized early and treated promptly in the emergency department.
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Hernandez et al. (2019) conducted a case report in Serotonin syndrome (n=1). Multiple serotonergic agents (bupropion, paroxetine, tramadol) was evaluated on Symptom resolution. A 53-year-old male developed serotonin syndrome after combining tramadol with bupropion and paroxetine, which resolved within 24 hours of discontinuing the agents and administering benzodiazepines.
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