Key result
Abrupt discontinuation of clozapine and venlafaxine linked to NMS-like symptoms in a schizophrenia patient.
Abrupt discontinuation of clozapine and venlafaxine can lead to NMS-like symptoms in patients with paranoid schizophrenia.
May warrant gradual tapering of clozapine and venlafaxine; this case leaves open the incidence and optimal protocols.
Neuroleptic malignant syndrome (NMS) is a potentially life‐threatening condition, which can occur as a complication in patients taking antipsychotic medications. Drs Kurien and Vattakatuchery present the case of a patient with paranoid schizophrenia who developed NMS‐like symptoms following abrupt discontinuation of clozapine and venlafaxine.
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Kurien et al. (2013) studied this question. Abrupt discontinuation of clozapine and venlafaxine led to the development of neuroleptic malignant syndrome-like symptoms in a patient with paranoid schizophrenia.
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