Key result
Risperidone use is linked to neuroleptic malignant syndrome that resolves upon drug cessation.
Why the study?
Does risperidone cause neuroleptic malignant syndrome in an elderly patient with bipolar affective disorder?
Case Report (n=1)
Does risperidone cause neuroleptic malignant syndrome in an elderly patient with bipolar affective disorder?
This case report suggests that risperidone, like other neuroleptics, can be associated with neuroleptic malignant syndrome.
May heighten NMS vigilance with risperidone in elderly bipolar patients; hypothesis-generating and requires confirmation in larger studies.
OBJECTIVE: To describe a case of neuroleptic malignant syndrome associated with risperidone. CLINICAL PICTURE: An elderly patient with bipolar affective disorder presented with neuroleptic malignant syndrome and relapse of hypomania after commencing risperidone. TREATMENT: Risperidone was ceased and the patient monitored closely. OUTCOME: The symptoms of neuroleptic malignant syndrome were resolved. CONCLUSION: To our knowledge this is the first such case reported, and suggests that risperidone, like other neuroleptics, is associated with neuroleptic malignant syndrome.
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Bonwick et al. (1996) conducted a case report in Bipolar affective disorder (n=1). Risperidone was evaluated on Neuroleptic malignant syndrome. Risperidone use in an elderly patient with bipolar affective disorder was associated with the development of neuroleptic malignant syndrome, which resolved upon cessation of the drug.
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