Key result
Aripiprazole dose escalation linked to reversible neuroleptic malignant syndrome in a bipolar patient.
Why the study?
Neuroleptic malignant syndrome is a serious medical emergency, but cases induced by aripiprazole are very rare.
Case Report (n=1)
Aripiprazole can rarely induce neuroleptic malignant syndrome, which resolves upon discontinuation of the drug.
Rare NMS with aripiprazole dose escalation warrants vigilance in bipolar disorder; leaves open true incidence and risk factors.
Neuroleptic malignant syndrome (NMS) is a serious medical emergency with significant fatality rates if not recognized and treated early. High-potency first-generation antipsychotics are reported to have more incidence of NMS. Aripiprazole-induced NMS is very rare, and here we report the case of a 38-year-old woman with bipolar illness disorder. The disorder started after escalating the dose and resolved after stopping the medicine.
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Ramdurg et al. (2021) conducted a case report in Bipolar illness disorder (n=1). Aripiprazole was evaluated on Neuroleptic malignant syndrome. Escalating the dose of aripiprazole induced neuroleptic malignant syndrome in a 38-year-old woman with bipolar illness disorder, which resolved after stopping the medication.
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