Key result
Hyaline membrane disease in preterm infants is linked to an ~83% lower chance of reflex vasoconstriction.
Why the study?
Does passive tipping to a 45-degree head-up position elicit reflex vasoconstriction differently in non-distressed preterm infants compared to those with hyaline membrane disease?
Population
40 preterm infants between 26 and 38 weeks gestation, comprising 13 non-distressed infants and 27 infants…
Comparison
Passive tipping to a 45-degree head-up position. vs Comparison of physiological responses between…
Design
Cross-sectional
Authors
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HMD-associated loss of reflex vasoconstriction warrants caution during head-up positioning in preterms; leaves open causal contribution to instability and need for prospective studies.
Observational (n=40)
Does passive tipping to a 45-degree head-up position elicit reflex vasoconstriction differently in non-distressed preterm infants compared to those with hyaline membrane disease?
Absolute Event Rate: 14.8% vs 84.6%
Reflex control of vascular tone is present in non-distressed preterm infants as early as 26 weeks gestation but is absent in those with hyaline membrane disease, likely due to maximally increased baseline vascular tone.
Waldman et al. (1979) conducted an observational in Hyaline membrane disease in preterm infants (n=40). Hyaline membrane disease vs. Non-distressed preterm infants was evaluated on Reflex vasoconstriction (increase in vascular tone and reduction in peripheral blood-flow) during 45º head-up tilting. Hyaline membrane disease in preterm infants was associated with an absence of reflex vasoconstriction during 45º head-up tilting (present in 14.8% vs 84.6% of non-distressed infants).
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