Aspergillus oryzae Fermented Brown Rice and Bran Supplement “FBRA” for Health and Cancer Prevention

Relationship between brown rice eating and health has been well recognized, but it is an empirical basis without solid scientific shreds of evidence.Fermented brown rice and bran with Aspergillus oryzae (FBRA) were developed almost 50 years ago to supplement white rice eating.We found spontaneous cancer remission among the FBRA users, so we resurvey the GENKI study cohort (Genmai Epidemiology, Nutrition, and Kenko Innovation; n = 1200) and found 180 FBRA users.We compared the effect of FBRA on bowel movement by brown rice and white rice eaters.One hundred eleven volunteers among the GENKI study provided their feces for intestinal microbiota analysis, so it became possible whether or not white rice eaters with FBRA intake showed a similar profile to brown rice eaters.FBRA users showed good bowel condition as well as brown rice eaters.Brown rice eaters with FIBRA enhanced the profile proportion of Faecalibacterium prausnitzi (6.2 to 8.9%), Blautia wexlerae (2.0 to 3.1%), Ruminococcus bromii (1.1 to 2.1%), and Bacteroides uniformis (0.9 to 3.3%).The principal component analysis showed a different pattern in the genmai and FBRA group.Long FBRA users by a separate questionnaire survey showed a low cancer incidence (p = 0.05), diabetes mellitus, dyslipidemia, and hypertension (p < 0.0001).Dietary fiber, γ-oryzanol, high vitamin and minerals, antioxidant activity, and various metabolites may contribute to multiple effects on health and disease prevention.The present paper provides information on new foodstuffs for cancer prevention.