Key result
Cyclic GMP modulators alter adrenergic neurotransmission, suggesting intrinsic cyclic GMP regulates vascular tone via EDRF.
Population
Isolated rabbit carotid artery (with and without endothelium)
Comparison
Cyclic GMP modulators and alpha-adrenoceptor… vs Endothelium-denuded preparations or untreated…
Design
Preclinical
Authors
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Does not alter clinical vascular management; leaves open whether cyclic GMP regulates human adrenergic tone.
Intrinsic levels of cyclic GMP may act as a regulator of adrenergic neurotransmission primarily due to basally released endothelium-derived relaxing factor.
Tesfamariam et al. (2008) studied Isolated rabbit carotid artery. Cyclic GMP Modulators (LY 83583, M & B 22948) vs. Endothelium-denuded preparations was evaluated on Vascular adrenergic neurotransmission and contractions. In isolated rabbit carotid arteries, cyclic GMP modulators altered adrenergic neurotransmission, suggesting intrinsic cyclic GMP regulates vascular tone via endothelium-derived relaxing factor.
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