December 1, 1992British Journal of PharmacologyOpen Access

Role of the l‐arginine‐NO pathway and of cyclic GMP in electrical field‐induced noradrenaline release and vasoconstriction in the rat tail artery

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Population

Perfused rat tail artery

Comparison

Pharmacological modulation of the L-arginine-NO… vs Control conditions

Design

Preclinical

Authors

BBBernard BucherCentre National de la Recherche Scientifique SOSylvin OuédraogoUniversité Joseph Ki-Zerbo MTMartin TschöplUniversity Hospital of Basel

Discussion

Member takes

Implication

Hypothesis-generating in rodent vessels; leaves open translation to human sympathetic vasoconstriction.

Structured PICO

Population

Perfused rat tail artery

Intervention

Pharmacological modulation of the L-arginine-NO pathway and cyclic GMP (using L-NAME, L-arginine, SIN-1, zaprinast, ANP, methylene blue, 8-bromo-cyclic GMP, dibutyryl-cyclic GMP)

Comparator

Control conditions (absence of modulators or use of inactive enantiomers like D-arginine)

Outcome

Vasoconstrictor responses to perivascular nerve stimulation and exogenous noradrenaline, and stimulation-evoked tritium overflow from [3H]-noradrenaline preloaded arteriessurrogate

Endothelial-derived NO attenuates neurally-induced and noradrenaline-evoked vasoconstriction in the rat tail artery via a postjunctional mechanism, while endogenous cGMP does not appear to regulate prejunctional noradrenaline release.

Cite This Study

Bucher et al. (1992) studied this question.

synapsesocial.com/papers/6a20de4534bef10fdaeb15d3 https://doi.org/10.1111/j.1476-5381.1992.tb13394.x

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Role of the l‐arginine‐NO pathway and of cyclic GMP in electrical field‐induced noradrenaline release and vasoconstriction in the rat tail artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of the l‐arginine‐NO pathway and of cyclic GMP in electrical field‐induced noradrenaline release and vasoconstriction in the rat tail artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider