Key result
L-NAME augments sympathetic pressor responses primarily by enhancing peripheral adrenal adrenaline release.
Why the study?
The complex peripheral effects of nitric oxide on sympathoadrenal catecholamine release and cardiovascular responses remain unclear.
Does L-NAME alter catecholamine release and vasopressor responses to spinal cord stimulation in pithed vagotomized rats?
Population
Pithed vagotomized rats
Comparison
N(G)-nitro-L-arginine methyl ester (L-NAME) vs vehicle (saline) with or without spinal cord stimulation and prazosin
Design
Preclinical experimental study in pithed rats
Authors
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May implicate peripheral adrenal catecholamine release in L-NAME pressor effects; leaves open central-peripheral contributions in humans.
Does L-NAME alter catecholamine release and vasopressor responses to spinal cord stimulation in pithed vagotomized rats?
Inhibition of nitric oxide synthesis augments the pressor response to sympathetic stimulation in rats, largely due to enhanced adrenal adrenaline release mediated by a peripheral mechanism.
Elayan et al. (2002) studied this question. N(G)-nitro-L-arginine methyl ester (L-NAME) vs. Vehicle (saline)-treated controls was evaluated on Plasma adrenaline and noradrenaline release and vasopressor responses to spinal cord stimulation. In pithed vagotomized rats, L-NAME augmented the pressor response to sympathetic stimulation largely due to enhanced adrenal adrenaline release mediated by a peripheral mechanism.
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