Key result
L-NAME increases vasoconstrictor responses by ~78% and reduces basal joint blood flow in rabbit knees.
Population
Normal and carrageenan-inflamed rabbit knee joints
Comparison
Close intra-arterial infusion of L-NAME for 45… vs Baseline measurements and comparison between…
Design
Preclinical
Authors
Loading...
Rabbit data extend nitric oxide's role in joint vasoregulation; leaves open translation to human arthritis.
Nitric oxide plays a significant role in maintaining basal joint blood flow and attenuating sympathetic vasoconstriction in both normal and acutely inflamed rabbit knee joints.
Najafipour et al. (1993) studied Normal and acutely inflamed rabbit knee joints. L-NAME (N omega-nitro_L-arginine methyl ester) vs. Basal values / normal joints was evaluated on Basal joint blood flow and vasoconstrictor responses. L-NAME infusion reduced basal joint blood flow by 36.4% in normal and 21.4% in inflamed rabbit knees, and increased vasoconstrictor responses to electrical stimulation by ~78%.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: