February 1, 1994Journal of Cardiovascular Pharmacology

Endogenous Nitric Oxide Modulates Vasopressor Responses, but Not Depressor Responses, to Spinal Sympathetic Nerve Stimulation in Pithed Rats

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Why the study?

Does L-NAME modulate vasopressor and depressor responses to spinal sympathetic nerve stimulation in pithed rats?

Population

Pithed rat preparation

Design

Preclinical

Authors

MMMargaret R. MacLeanVascular / Pulmonary Vascular JGJohn R. GrahamDePaul University JMJ.C. McGrathUniversity of Minnesota Medical Center

Discussion

Member takes

Implication

Caution against clinical translation from pithed-rat data; extends preclinical evidence on NO modulation of sympathetic vasoconstriction.

Structured PICO

Does L-NAME modulate vasopressor and depressor responses to spinal sympathetic nerve stimulation in pithed rats?

Population

Pithed rat preparation

Intervention

N omega-nitro-L-arginine methylester (L-NAME) 1, 5, and 10 mg/kg

Outcome

Vasopressor and depressor responses to segmental sympathetic nerve stimulationsurrogate

Inhibition of endogenous NO synthesis potentiates sympathetic vasoconstriction but does not mediate systemic vascular depressor responses in pithed rats.

Cite This Study

MacLean et al. (1994) studied this question.

synapsesocial.com/papers/6a8bd0d3c12eaf65c8b21cb9 https://doi.org/10.1097/00005344-199402000-00021

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Endogenous Nitric Oxide Modulates Vasopressor Responses, but Not Depressor Responses, to Spinal Sympathetic Nerve Stimulation in Pithed Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endogenous Nitric Oxide Modulates Vasopressor Responses, but Not Depressor Responses, to Spinal Sympathetic Nerve Stimulation in Pithed Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider