Key result
Murine norovirus infection of macrophages induces intrinsic apoptosis, and pan-caspase inhibition or BAX/BAK deficiency perturbs viral replication rates and delays virus release and cell death.
Why the study?
Noroviruses cause acute gastroenteritis, but how they cause disease, modulate innate immunity, and harness specific programmed cell death pathways for replication remains poorly understood.
Population
Macrophages infected with murine norovirus
Comparison
Pan-caspase inhibition or BAX and BAK deficiency vs unmanipulated infection
Design
Preclinical in vitro laboratory study
Authors
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Apoptosis modulation may limit norovirus replication in macrophages; hypothesis-generating for human antiviral strategies.
Murine norovirus harnesses intrinsic apoptosis pathways to increase viral burden and release in macrophages.
Deerain et al. (2023) studied Murine norovirus infection. Murine norovirus (MNV) infection was evaluated on Programmed cell death and viral replication. Murine norovirus infection of macrophages induces intrinsic apoptosis, and pan-caspase inhibition or BAX/BAK deficiency perturbs viral replication rates and delays virus release and cell death.
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