Key result
Hepatic resection for primary hepatic angiosarcoma yields ~18 months median overall survival.
Why the study?
Primary hepatic angiosarcoma is a rare tumor entity where radical surgical resection is considered the best treatment, and the authors aimed to report their surgical experience.
Does hepatic resection improve survival in patients with primary hepatic angiosarcoma?
Observational (n=9)
No
Does hepatic resection improve survival in patients with primary hepatic angiosarcoma?
Radical surgical resection of primary hepatic angiosarcoma can achieve complete tumor removal and offers a chance for long-term survival, with a median overall survival of 59 months after R0 resection.
May support R0 resection for survival in primary hepatic angiosarcoma; leaves open need for prospective data before practice change.
BACKGROUND: Primary hepatic angiosarcoma (PHA) is a rare tumor entity. Radical surgical resection is currently considered the best treatment choice. The aim of this analysis is to report our experience with surgery for PHA. METHODS: All resections of PHA from 01/2002 until 06/2017 were identified from our prospective institutional database. All cases were re-confirmed by a second pathologist. We analyzed completeness of resection, overall (OS) and disease-free survival (DFS). RESULTS: Nine patients with PHA underwent hepatic resection. Median follow-up after surgery was 15.5 months (range: 3-144). At last follow-up 4/9 patients were alive, three of them without recurrence 15, 21 and 144 months after surgery. Five patients developed PHA recurrence. Four of these died 3 to 17 months after surgery. One patient with PHA recurrence is alive 15 months after surgery. Another patient without PHA recurrence died 59 months after surgery from pancreatic cancer. Median OS and DFS after resection was 18 months (range: 3-144 months) and 10 months (range: 2-144 months), respectively. After R-0 resection (n = 8), the median OS and DFS was 59 and 11 months. CONCLUSIONS: Resection of PHA is the only approach to achieve complete tumor removal and offers a chance for long-term survival and should be evaluated in cases of PHA.
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Tripke et al. (2019) conducted an observational in Primary hepatic angiosarcoma (n=9). Hepatic resection was evaluated on Median overall survival. Hepatic resection for primary hepatic angiosarcoma resulted in a median overall survival of 18 months and a median disease-free survival of 10 months, with R0 resection yielding 59 months.
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