Progress on the Synthesis and Applications of Thiocyanates

Thiocyanates (RSCN) are important synthetic intermediates, which have been widely used for the synthesis of pesticides, medicines and materials.In recent years, great advances in the synthesis and transformations of this class of compounds have been made, and many synthetic applications of those compounds have been emerged.In this review, the synthetic methods and transformations of thiocyanates are introduced systematically, which may provide assistance for the studies of thiocyanates in this area.Keywords thiocyanates; synthetic methods; application 硫氰酸酯(RSCN)是一类含有硫氰基官能团的重要 氮硫类化合物(图 1), 具有多种生物活性, 如抑制酶活 性、杀虫活性、抗微生物活性等, 在医药和农药等领域 有着重要的应用价值 [1～5] .此外, 硫氰酸酯类化合物也 广泛应用于有机合成领域 [6～11] .作为重要的有机合成中 间体, 硫氰酸酯通过简单转化就可得到硫醇、硫醚、异 硫氰酸酯、含硫杂环等多种有机硫化物, 同时它还可作 为氰化试剂很好地参与反应.由于硫氰酸酯具有良好的 生物活性和广阔的应用前景, 引起了有机合成工作者们 的浓厚研究兴趣.近几十年来, 合成化学家们对硫氰酸酯类化合物的 合成与应用展开了较为深入的研究与探索.