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Mixtures of fibrinogen degradation products (FDP) from purified fibrinogen, as well as purified products from defined stages of fibrinogen degradation have been tested as to their influence on the thrombin clotting time. The prolongation of the thrombin clotting time exerted by various FDP was found to depend on the relative concentrations of FDP and fibrinogen in the test system. In addition, decreasing concentrations of fibrinogen increased the relative inhibitory influence of FDP. N‐terminal amino acid analysis revealed that the strong effect exerted by purified stage II FDP was mainly due to polymerization inhibition, while the moderate effect exerted by products (D + E) was due to combined thrombin and polymerization inhibition.
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Arnesen et al. (1973) studied this question.
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