Key result
Recent advances in stem cell biology and cellular reprogramming offer exciting new strategies for cardiac regeneration in ischemic heart disease.
This review summarizes recent advances in understanding cardiac regeneration mechanisms and the potential of stem cell biology and cellular reprogramming for treating ischemic heart disease.
Promising stem cell strategies for ischemic heart disease remain investigational; leaves open clinical translation pending rigorous trials.
More people die every year from ischemic heart disease than any other disease. Because the human heart lacks sufficient ability to replenish the damaged cardiac muscles, extensive research has been devoted toward understanding the homeostatic and regenerative potential of the heart and to develop regenerative therapies for heart disease. Here, we discuss recent advances in the understanding of mechanisms governing heart growth during homeostasis or injury, including those from observational studies in humans and experimental research in animal models of cardiac regeneration. We also discuss how progress in stem cell biology and cellular reprogramming has enabled exciting new strategies for cardiac regeneration.
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Li et al. (2016) conducted a review in Ischemic heart disease. Cardiac regeneration therapies was evaluated. Recent advances in stem cell biology and cellular reprogramming offer exciting new strategies for cardiac regeneration in ischemic heart disease.