Key result
Greater probe force improves atomic force microscopy lateral resolution to ~13% above known LDL size.
Population
Computer model based on the elastic properties of rubber and isolated low-density lipoproteins (LDL)
Comparison
Greater probe force (26% vertical compression) vs Simple convolution / lower probe force
Design
Other
Authors
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May refine LDL sizing accuracy in research AFM; leaves open validation for cardiovascular applications.
Greater probe force in atomic force microscopy can improve lateral resolution of deformable specimens like LDL, provided the response remains elastic.
Yang et al. (1996) studied Deformable specimens (low-density lipoproteins). Greater probe force (vertical compression) vs. Lower probe force / simple convolution was evaluated on Lateral resolution (full width at half-height). Greater probe force in atomic force microscopy improves lateral resolution, with 26% vertical compression yielding a lateral size only 13% larger than the known size of low-density lipoproteins.
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