Why the study?
To investigate the expression of serum SAH, IL-1β, Hcy, TNF-α, and BDNF in CHD and their relationship with the degree of coronary artery disease.
Do serum levels of SAH, IL-1β, Hcy, TNF-α, and BDNF correlate with the severity of coronary stenosis in patients with coronary heart disease?
Observational (n=277)
No
Do serum levels of SAH, IL-1β, Hcy, TNF-α, and BDNF correlate with the severity of coronary stenosis in patients with coronary heart disease?
Effect estimate: r = 0.421, 0.533, 0.301, 0.265, 0.678
p-value: p=0.016, 0.009, 0.023, 0.036, 0.004
Serum levels of SAH, IL-1β, Hcy, TNF-α, and BDNF are elevated in patients with coronary heart disease and correlate positively with the number of stenotic vessels, suggesting their potential utility as biomarkers for disease severity.
Should not yet change practice; leaves open prospective validation of these markers for stenosis severity.
BACKGROUND: To investigate the expression of serum S-adenosylhomocysteine (SAH), interleukin-1β (IL-1β), serum homocysteine (Hcy), tumor necrosis factor-α (TNF-α) and brain derived neurotrophic factor (BDNF) in coronary heart disease and their relationship with the degree of coronary artery disease. METHODS: A total of 132 patients with coronary heart disease (CHD) from March 2020 to April 2021 were included in this retrospective study. The experimental group was composed of CHD patients, including single-vascular group (46 cases), dual-vascular group (49 cases), and multi-vascular group (37 cases). 145 healthy subjects during the same period for physical examination constituted the control group. RESULTS: The levels of SAH, IL-1β, Hcy, TNF-α and BDNF in single-vascular group, dual-vascular group and multi-vascular group were higher than that in control group, and the differences were statistically significant (P < 0.05). The serum levels of SAH, IL-1β, Hcy, TNF-α and BDNF in multi-vascular group were higher than those in single-vascular group and dual-vascular group, and the serum levels of SAH, IL-1β, Hcy, TNF-α and BDNF in dual-vascular group were higher than those in single-vascular group, with statistical significance (P < 0.05). Kendall's tau-b correlation showed that the levels of SAH, IL-1β, Hcy, TNF-α and BDNF were positively correlated with the number of stenosis vessels (r = 0.421, 0.533, 0.301, 0.265, 0.678, P = 0.016, 0.009, 0.023, 0.036, 0.004). CONCLUSION: SAH, IL-1β, Hcy, TNF-α and BDNF in serum of patients with CHD can be used as effective biological indicators to monitor the degree of CHD and severity of coronary stenosis.
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Wu et al. (2022) conducted an observational in Coronary heart disease (n=277). Serum SAH, IL-1β, Hcy, TNF-α, and BDNF levels vs. Healthy subjects was evaluated on Correlation between biomarker levels and the number of stenosis vessels (r = 0.421, 0.533, 0.301, 0.265, 0.678, p=0.016, 0.009, 0.023, 0.036, 0.004).
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