Why the study?
To examine the relationship and combined predictive value of serum Tenascin-C, the neutrophil to high-density lipoprotein cholesterol ratio, and the severity of coronary artery lesions in patients with coronary heart disease.
Do serum TNC levels and NHR ratio correlate with and predict the severity of coronary artery lesions in patients undergoing coronary angiography?
Population
119 patients with coronary heart disease and 69 negative controls undergoing coronary angiography
Comparison
Coronary heart disease vs negative controls and across lesion severity groups
Key result
Serum TNC (OR 1.330) and NHR (OR 2.097) were identified as independent risk factors for moderate-to-severe coronary artery stenosis, with their combination yielding a predictive AUC of 0.852.
Authors
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TNC and NHR may aid CAD severity assessment; observational data leave open prospective validation before clinical adoption.
Cross-Sectional (n=188)
No
Do serum TNC levels and NHR ratio correlate with and predict the severity of coronary artery lesions in patients undergoing coronary angiography?
Odds Ratio: 2.097 (95% CI 1.42–3.095)
p-value: p=<0.001
Serum TNC levels and the NHR ratio are significantly elevated in patients with coronary heart disease and their combination offers strong predictive value for moderate-to-severe coronary artery stenosis.
海新 高 (2025) conducted a cross-sectional in Coronary Heart Disease (n=188). Serum TNC levels and NHR ratio vs. Lower levels / Non-CHD patients was evaluated on Moderate-to-severe coronary artery stenosis (NHR ratio) (OR 2.097, 95% CI 1.420-3.095, p=<0.001). Serum TNC (OR 1.330) and NHR (OR 2.097) were identified as independent risk factors for moderate-to-severe coronary artery stenosis, with their combination yielding a predictive AUC of 0.852.
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