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March 8, 2026Frontiers in Cardiovascular MedicineOpen Access

Correlation of neutrophil/lymphocyte, monocyte/lymphocyte, and CRP/ALB ratios with the extent of coronary artery lesions and their predictive value

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Authors

LCLijuan ChenJRJixian RaoSZShan Zhang

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Overview

Retrospective analysis investigates the predictive value of inflammatory ratios in coronary artery disease, suggesting their significance.

Key Points

  • This research aims to explore how certain inflammatory ratios correlate with the severity of coronary artery disease and their predictive values.
  • Retrospective analysis of 510 patients undergoing coronary angiography for suspected coronary artery disease.
  • Comparison of neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), and CRP/ALB levels between CHD patients and a control group.
  • Evaluation of coronary stenosis severity using the Gensini score and statistical analyses using Pearson and Spearman coefficients.
  • Logistic regression was utilized to identify independent risk factors for CHD.
  • NLR, MLR, and CRP/ALB levels were significantly higher in CHD patients compared to controls (P < 0.001).
  • Positive correlations were found between NLR (r = 0.546), MLR (r = 0.445), CRP/ALB (r = 0.500), and the Gensini score in CHD patients.
  • Independent predictors of CHD included male gender, hypertension, diabetes, hyperlipidemia, and elevated inflammatory ratios, while HDL-C was protective.
  • The combined diagnostic capability of NLR, MLR, and CRP/ALB showed an AUC of 0.931, significantly higher than using single indicators.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69ada873bc08abd80d5bb5d7https://doi.org/10.3389/fcvm.2026.1679198
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Also Consider

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