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June 7, 2026Journal of Medical BiochemistryOpen Access

Lower serum TRF and LGP2 levels are linked to CHD and worse cardiac function.

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Why the study?

To explore the correlation between serum T cell replacing factor (TRF) and liver glutathione peroxidase 2 (LGP2) levels and cardiac function in patients with coronary heart disease.

Population

252 patients with CHD and 240 healthy controls

Comparison

Patients with CHD vs healthy controls

Design

Case-control study

Key result

Serum TRF and LGP2 levels were significantly lower in patients with coronary heart disease compared to healthy controls and correlated with worse cardiac function indicators (P<0.05).

Authors

TCTianhao CuiSZShuai ZhaoYXYing Xia

Discussion

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Overview

Lower TRF and LGP2 levels associate with CHD severity; hypothesis-generating, requiring prospective validation before clinical use.

Key Points

  • This research aims to investigate the relationship between serum TRF and LGP2 levels and cardiac function in patients with coronary heart disease (CHD).
  • Evaluated 252 patients with CHD and 240 healthy controls from October 2023 to October 2025.
  • Measured serum levels of TRF, LGP2, BNP, and CK-MB using enzyme-linked immunosorbent assays (ELISA).
  • Analyzed cardiac function using Doppler ultrasound and Pearson correlation for TRF and LGP2 levels against cardiac function markers.
  • Patients with CHD had significantly lower TRF and LGP2 levels compared to controls (P<0.05).
  • Higher NYHA grades showed significantly lower LVEF and CO, along with lower TRF and LGP2 levels (P<0.05).
  • Negative correlations were found between TRF and LGP2 levels and BNP, CK-MB, LVESD, LVEDD, LV mass, and IVS (P<0.05).

Study Design

Type

Case-Control (n=492)

Structured PICO

P
Population
492 participants comprising 252 patients with coronary heart disease and 240 healthy controls.
C
Comparator
240 healthy patients who had physical examinations at the same institution
O
Outcome
Correlation between serum TRF and LGP2 levels and cardiac function markers (BNP, CK-MB, LVEF, LVESD, LVEDD, CO, IVS, LV mass)surrogate

Main Result

p-value: p=<0.05

Serum TRF and LGP2 levels are significantly decreased in patients with coronary heart disease and correlate strongly with worsening cardiac function and structural remodeling.

Cite This Study

Cui et al. (2026) conducted a case-control in Coronary heart disease (n=492). Serum TRF and LGP2 levels vs. Healthy controls was evaluated on Correlation between serum TRF and LGP2 levels and cardiac function markers (p=<0.05). Serum TRF and LGP2 levels were significantly lower in patients with coronary heart disease compared to healthy controls and correlated with worse cardiac function indicators (P<0.05).

synapsesocial.com/papers/6a250c7d7def13d035e1caadhttps://doi.org/10.5937/jomb0-66239
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