What question did this study set out to answer?

Develop a direct catalytic strategy to construct indole ring systems from (o-iodoanilinoalkyl)allene starting materials.

December 31, 2001Synlett

A Novel Method for Direct Construction of Indole Skeletons by Intramolecular Carbopalladation of Allenes Followed by Nucleophilic Substitution

View Full Paper

Ask AI

Bookmark

Authors

KHKunio HiroiOhu University YHYuko HiratsukaShohoku College KWKazuhiro WatanabeIHI Corporation (Czechia)

Discussion

Member takes

Implication

Experimental study demonstrates direct synthesis of indole derivatives via tandem carbopalladation and amination, indicating an efficient catalytic route to complex heterocycles.

Key Points

Develop a direct catalytic strategy to construct indole ring systems from (o-iodoanilinoalkyl)allene starting materials.
Treated (o-iodoanilinoalkyl)allene compounds with a palladium catalyst to induce intramolecular cascade cyclization.
Promoted intramolecular carbopalladation of the allene followed by nucleophilic amination of intermediate π-allylpalladium complexes.
Successfully delivered indole derivatives in fairly good chemical yields.
Achieved tandem carbon-carbon and carbon-nitrogen bond formation in a single direct catalytic sequence.

Cite This Study

Hiroi et al. (2001) studied this question.

synapsesocial.com/papers/6aa4bc29e6340fee3c94df33 https://doi.org/10.1055/s-2001-10787

View Full Paper

Ask AI

Bookmark

Implication

Experimental study demonstrates direct synthesis of indole derivatives via tandem carbopalladation and amination, indicating an efficient catalytic route to complex heterocycles.

A Novel Method for Direct Construction of Indole Skeletons by Intramolecular Carbopalladation of Allenes Followed by Nucleophilic Substitution

Discussion

Member takes

Implication

Key Points

Cite This Study

A Novel Method for Direct Construction of Indole Skeletons by Intramolecular Carbopalladation of Allenes Followed by Nucleophilic Substitution

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider