What question did this study set out to answer?

This research aims to develop an efficient method for synthesizing bisindole scaffolds using palladium-catalyzed reactions.

May 3, 2026Organic & Biomolecular Chemistry0 citations

Synthesis of bisindoles scaffolds by palladium-catalyzed allylic alkylation of N-aminoindole with ortho-iodoaryl allenes

CDChenyue DingYangzhou University YYYuan YinYangzhou University EHEnyu HuYangzhou University

Key Points

This research aims to develop an efficient method for synthesizing bisindole scaffolds using palladium-catalyzed reactions.
Utilized palladium-catalyzed domino allylic alkylation
Combined ortho-iodoaryl allenes with N-aminoindoles
Synthesized various diversely substituted bisindoles
Successfully synthesized a variety of bisindole scaffolds
Achieved high efficiency in reaction conditions
Demonstrated diversity in substituent combinations

Abstract

A highly efficient Pd-catalyzed domino allylic alkylation of ortho-iodoaryl allenes with N-aminoindoles has been developed. This protocol enables the synthesis of a variety of diversely substituted N−N scaffold-containing bisindoles under...

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