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April 12, 2025Journal of Cardiothoracic SurgeryOpen Access

Elderly women with ACS exhibit higher anxiety and depression up to 12 weeks post-PCI versus men.

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Why the study?

Psychological factors correlate with coronary heart disease, and gender discrepancies in mental health following PCI for acute coronary syndrome patients warrant investigation.

Does female gender increase anxiety and depression symptoms in elderly patients with acute coronary syndrome after percutaneous coronary intervention?

Comparison

113 female patients vs 121 male patients

Design

Observational cohort study

Follow-up

12 weeks

Key result

Elderly female patients with acute coronary syndrome exhibited significantly higher anxiety and depression scores up to 12 weeks following percutaneous coronary intervention compared to elderly male patients.

Authors

JLJie LiSLShantao LiuCYChangqing Ye

Discussion

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Member takes

Overview

May warrant gender-specific psychological screening after PCI in elderly women with ACS; observational data leaves open causality and need for RCTs.

Study Design

Type

Observational (n=234)

Multicenter

No

Structured PICO

Does female gender increase anxiety and depression symptoms in elderly patients with acute coronary syndrome after percutaneous coronary intervention?

P
Population
234 elderly adults (aged ≥ 60 years) with acute coronary syndrome who underwent percutaneous coronary intervention, followed for 12 weeks to assess gender differences in anxiety and depression.
E
Exposure
Female gender (observational comparison)
C
Comparator
Male gender
O
Outcome
Anxiety and depression assessed using the Self-rating anxiety scale (SAS) and Self-rating depression scale (SDS) before PCI and at 1, 4, and 12 weeks post-procedurepatient reported

Main Result

Absolute Event Rate: 48.92% vs 44.89%

p-value: p=0.041

Elderly female patients with ACS undergoing PCI are more susceptible to anxiety and depression post-procedure compared to males, highlighting the need for gender-specific psychological support.

Limitations

  • Observational study design limits the ability to infer causal relationships
  • Focus exclusively on elderly patients limits generalizability to other age groups
  • Susceptible to memory and information bias due to reliance on self-assessment questionnaires
  • Limited sample size may compromise the reliability and representativeness of the results

Cite This Study

Li et al. (2025) conducted an observational in Acute coronary syndrome (ACS) (n=234). Female gender vs. Male gender was evaluated on Self-rating anxiety scale (SAS) score at 12 weeks post-PCI (p=0.041). Elderly female patients with acute coronary syndrome exhibited significantly higher anxiety and depression scores up to 12 weeks following percutaneous coronary intervention compared to elderly male patients.

synapsesocial.com/papers/6aa4c609054c487ec1dc37behttps://doi.org/10.1186/s13019-025-03427-5
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