Key result
Diabetic rat bladders exhibit greater spontaneous activity and contractile responses to electrical stimulation versus controls.
Population
Bladder strips from streptozotocin-induced diabetic rats, control rats, and sucrose-drinking rats
Comparison
Electrical field stimulation vs Bladder strips from control and sucrose-drinking…
Design
Preclinical
Authors
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May inform diabetic cystopathy models in rats; leaves open translation to human bladder dysfunction.
Bladder strips from streptozotocin-induced diabetic rats exhibit increased excitability to electrical field stimulation compared to controls, involving both neurogenic and myogenic components.
Tammela et al. (1994) studied Streptozotocin-induced diabetes. Streptozotocin-induced diabetes vs. Control and sucrose-drinking rats was evaluated on Response of bladder strips to electrical field stimulation. Bladder strips from streptozotocin-diabetic rats exhibited greater spontaneous activity and contractile responses to electrical field stimulation compared to control or sucrose-drinking rats.