Key result
Experimental diabetes increases bladder base contractile response to acetylcholine by ~66% in rats.
Why the study?
The effects of streptozocin-induced diabetes on urinary bladder responses to autonomic agents in different bladder regions were not fully characterized.
Population
Streptozocin-diabetic rats at 6 weeks and 47 weeks of diabetes
Comparison
Response to acetylcholine, phenylephrine, and isoproterenol in bladder body vs bladder base
Design
Preclinical experimental study
Follow-up
6 weeks and 47 weeks
Authors
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Hypothesis-generating for diabetic bladder dysfunction; does not support clinical practice changes without human data.
Streptozocin-induced diabetes in rats leads to progressive, region-specific increases in urinary bladder responsiveness to autonomic stimuli, suggesting enhanced postsynaptic responsiveness associated with diabetic neuropathy.
Kolta et al. (1985) studied Streptozocin-induced diabetes. Streptozocin-induced diabetes vs. Non-diabetic controls (implied) was evaluated on Response of the urinary bladder body and base to autonomic agents. Streptozocin-induced diabetes in rats increased bladder base contractile response to acetylcholine by 39% at 6 weeks and 66% at 47 weeks.
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