Key result
Mesencephalic locomotor region stimulation in cats modulates heart rhythm via central respiratory and stepping rhythms.
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This preclinical study demonstrates that cardiac, respiratory, and stepping rhythms interact hierarchically, leading to a new proposed model of biological oscillators.
Interactions are described of central origin between respiratory, cardiac and stepping rhythms during fictive locomotion in paralyzed, vagotomized, and decerebrated cats. Fictive locomotion was induced by tonic electrical stimulation of the mesencephalic locomotor region (MLR). The coherence between heart beat fluctuation, the efferent discharges of the phrenic, and the lateral gastrocnemius nerves was used to evaluate the strength of the coupling between those three rhythms. The heart beat rhythm was modulated by the centrally generated respiratory and stepping rhythms. The central respiratory rhythm was modulated by the centrally generated stepping rhythm. Based on the present findings, we have proposed a new model concerning the functional hierarchical structures of the three biological oscillators.
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Kawahara et al. (1994) studied Paralyzed, vagotomized, and decerebrated cats. Tonic electrical stimulation of the mesencephalic locomotor region (MLR) was evaluated on Coherence between heart beat fluctuation, efferent discharges of the phrenic, and lateral gastrocnemius nerves. Tonic electrical stimulation of the mesencephalic locomotor region in decerebrated cats showed that heart beat rhythm was modulated by centrally generated respiratory and stepping rhythms.
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