Key result
lncRNAs regulate cardiomyocyte apoptosis by acting as endogenous miRNA sponges to influence target gene expression.
Why the study?
Although studies have uncovered novel lncRNA-mediated regulation of cardiovascular diseases, knowledge of the underlying mechanisms remains limited.
This review summarizes current knowledge on how long non-coding RNAs regulate cardiomyocyte apoptosis in cardiovascular diseases.
Answers are grounded in this paper and cite their sources.
Does not alter clinical practice; leaves open lncRNA-targeted therapies for cardiomyocyte apoptosis in cardiovascular disease.
Long non-coding RNAs (lncRNAs) have gained more attention in recent years as a potential new regulator of nearly all biological regulation.LncRNAs are over 200 nucleotides in length, and it can interact with other non-coding RNAs or specific proteins to influence the gene expression.Cardiomyocyte apoptosis is associated with cardiovascular diseases.Accumulating studies have uncovered novel lncRNAs-mediated regulation of cardiovascular diseases; however, the knowledge of the mechanisms by how to act is still limited.This review highlights the role of lncRNAs involved in cardiomyocyte apoptosis with a focus on the regulatory axis.These examples may provide helpful insights on how lncRNAs interfere with cardiomyocyte apoptosis.
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Chen et al. (2019) conducted a review in Cardiomyocyte apoptosis. Long non-coding RNAs (lncRNAs) was evaluated. Long non-coding RNAs (lncRNAs) act as crucial regulators of cardiomyocyte apoptosis, primarily by functioning as endogenous sponges for microRNAs to influence target gene expression.
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