Key result
Higher SBP is linked to ~6% greater odds of elevated baPWV in treated hypertensive patients.
Why the study?
Little information was available regarding associations between brachial-ankle pulse wave velocity and blood pressure indices in treated hypertensive patients.
Are blood pressure indices associated with brachial-ankle pulse wave velocity in treated hypertensive adults?
Cross-Sectional (n=14,598)
Yes
Are blood pressure indices associated with brachial-ankle pulse wave velocity in treated hypertensive adults?
Odds Ratio: 1.056 (95% CI 1.053–1.059)
p-value: p=<0.001
In treated hypertensive patients, higher systolic, diastolic, pulse, and mean arterial pressures are independently associated with increased arterial stiffness as measured by brachial-ankle pulse wave velocity.
Higher SBP was associated with elevated baPWV in treated hypertension; hypothesis-generating and should not yet change practice.
Brachial-ankle pulse wave velocity (baPWV), as a marker of arterial stiffness, has been demonstrated to be associated with blood pressure (BP) and onset of hypertension. However, little information is available on the associations between baPWV and BP indices [systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), mean arterial pressure (MAP)] in treated hypertensive patients. We aimed to assess the associations between BP indices and baPWV. In this cross-sectional study, 14,598 hypertensive patients from China Stroke Primary Prevention Trial (CSPPT) at the exit visit of the trial were analyzed. Elevated baPWV was defined as ≥18.3 m/s. Multivariate linear and logistic regression analyses were performed to evaluate the associations of BP indices with baPWV and elevated baPWV. Moreover, the smooth curve fitting (penalized spline method) was conducted. Multivariate linear regression analyses showed that continuous SBP, DBP, PP and MAP were independently and positively associated with baPWV (β = 0.081, 0.084, 0.078 and 0.115, respectively, all P < 0.001). Compared with controlled SBP group (<140 mm Hg), uncontrolled SBP (≥140 mm Hg) was significantly associated with higher baPWV [β = 2.234, 95% confidence interval (CI): 2.137-2.332]. Similarly, compared with controlled DBP group (<90 mm Hg), uncontrolled DBP (≥90 mm Hg) was significantly associated with higher baPWV (β = 1.466, 95%CI: 1.341-1.590). Multiple logistic analyses also showed that SBP, DBP, PP and MAP were significantly and positively associated with elevated baPWV (OR = 1.056, 1.049, 1.052, and 1.075, respectively, all P < 0.001). The fully-adjusted smooth curve fitting presented a linear association between BP indices with baPWV. In conclusion, among treated hypertensive patients, SBP, DBP, PP and MAP levels were independently and positively associated with baPWV and elevated baPWV, suggesting that baPWV might be a way to predict uncontrolled BP.
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Hu et al. (2019) conducted a cross-sectional in Treated hypertension (n=14,598). Continuous systolic blood pressure was evaluated on Elevated brachial-ankle pulse wave velocity (≥18.3 m/s) (OR 1.056, 95% CI 1.053-1.059, p=<0.001). Among treated hypertensive patients, continuous systolic blood pressure was independently and positively associated with elevated brachial-ankle pulse wave velocity (OR 1.056).
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