Key result
Progressive insulin resistance in prehypertension is linked to higher glucose and triglycerides and lower HDL.
Cross-Sectional (n=126)
p-value: p=<0.01
At least one-third of patients with prehypertension are insulin resistant and display metabolic abnormalities, highlighting a subgroup that may require enhanced surveillance to prevent cardiovascular disease.
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Heterogeneity in insulin sensitivity among prehypertensives may refine CVD risk estimates; leaves open whether assessment should guide management.
Knobler et al. (2011) conducted a cross-sectional in Prehypertension (n=126). Insulin resistance vs. Insulin-sensitive group was evaluated on Plasma glucose, triglyceride, and high-density lipoprotein cholesterol concentrations (p=<0.01). Progressive degrees of insulin resistance in prehypertensive individuals were associated with significant increases in plasma glucose and triglycerides and decreases in HDL cholesterol (p<0.01).
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