Key result
Takayasu arteritis linked to ~81% prevalence of abnormal four-limb blood pressure or baPWV versus controls.
Why the study?
Takayasu arteritis is frequently misdiagnosed or missed, prompting analysis of four-limb blood pressure and brachial-ankle pulse wave velocity characteristics to aid disease detection.
Do four-limb blood pressure and brachial-ankle pulse wave velocity parameters differ between patients with Takayasu arteritis and matched controls?
Case-Control (n=182)
No
Do four-limb blood pressure and brachial-ankle pulse wave velocity parameters differ between patients with Takayasu arteritis and matched controls?
Absolute Event Rate: 80.8% vs 10.4%
p-value: p=0.000
Four-limb blood pressure and brachial-ankle pulse wave velocity parameters are frequently abnormal in patients with Takayasu arteritis, providing a useful non-invasive screening tool for vascular lesions.
Supports four-limb BP/PWV screening in Takayasu arteritis; leaves open whether it alters management or outcomes.
Purpose: Takayasu arteritis (TA) is a rare disease, which is frequently misdiagnosed or its diagnosis can be missed. This study aimed to analyse the characteristics of four-limb blood pressure (4LBP) and brachial-ankle pulse wave velocity (baPWV) in patients with TA, which could be useful in disease detection.Materials and Methods: We consecutively enrolled 182 patients with TA at Fuwai Hospital between January 2013 and January 2016. Pulse pressure (PP), pulsatile index (PI), inter-arm systolic blood pressure (SBP) difference (IASBPD), inter-leg SBP difference (ILSBPD), ankle–brachial index (ABI), baPWV, and inter-side baPWV difference (ΔbaPWV) were analysed and compared with those of age-, sex-, and SBP-matched participants without cardiovascular diseases.Results: In the TA group, the diastolic blood pressure was lower (67.4 ± 23.7 vs 84.1 ± 15.0 mmHg), PP was larger (69.7 ± 23.6 vs 53.7 ± 10.6 mmHg), PI was higher (1.3 ± 2.1 vs. 0.6 ± 0.1 mmHg), IASBPD was larger (18.2 ± 24.1 vs 4.2 ± 3.3 mmHg), and ILSBPD was larger (10.7 ± 15.0 vs 5.3 ± 4.1 mmHg) than those of the controls (all p < 0.01). Moreover, the proportions of PP >70 mmHg (36.8% vs 4.4%), PI > 1.0 (40.1% vs 2.2%), IASBPD >15 mmHg (34.6% vs. 0%), highest ABI >1.4 (17.6% vs. 0%), ILSBPD >15 mmHg (14.8% vs. 3.3%), lowest ABI < 0.9 (24.7% vs 2.2%), and ΔbaPWV > 185 cm/s (28.6% vs. 1.1%) were significantly greater in the TA group than in the control group (all p < 0.01). Approximately 80.8% of patients with TA (vs. 10.4% of controls) presented with at least one of these seven parameters (p = 0.000).Conclusion: The characteristics of 4LBP and baPWV in most patients with TA were abnormal, which helped us perform non-invasive primary screening and comprehensive evaluation of vascular lesions in such patients.
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Chen et al. (2022) conducted a case-control in Takayasu arteritis (n=182). Takayasu arteritis vs. Age-, sex-, and SBP-matched participants without cardiovascular diseases was evaluated on Presence of at least one of seven abnormal 4LBP or baPWV parameters (p=0.000). Takayasu arteritis was associated with a significantly higher prevalence of abnormal four-limb blood pressure or pulse wave velocity parameters compared to matched controls (80.8% vs 10.4%, p=0.000).
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