Key result
Pregnant women with GDM have ~23% lower serum irisin levels versus healthy controls.
Why the study?
Gestational diabetes mellitus is accompanied by oxidative stress, but the association between circulating irisin and betatrophin levels and GDM remains controversial.
Are serum irisin and betatrophin levels altered and associated with oxidative stress in pregnant women with gestational diabetes mellitus?
Cross-Sectional (n=90)
No
Are serum irisin and betatrophin levels altered and associated with oxidative stress in pregnant women with gestational diabetes mellitus?
Serum irisin is decreased in gestational diabetes mellitus and may serve as a useful biomarker, although it does not correlate with oxidative stress markers.
Answers are grounded in this paper and cite their sources.
Lower irisin in GDM may support biomarker evaluation; leaves open any link to oxidative stress.
Background. Irisin and betatrophin are polypeptide hormones implicated in glucose metabolism and insulin resistance (IR). Gestational diabetes mellitus (GDM) is accompanied by oxidative stress (OS) and the association between circulating irisin and betatrophin levels and GDM is controversial. The present study aimed to investigate the association of second-trimester irisin, betatrophin concentrations and their correlations between serum OS markers in GDM patients. Methods. The study included 45 GDM patients and 45-age matched pregnant women as controls. Serum fasting glucose, HOMA-IR, ischemia modified albumin (IMA), total oxidative stress (TOS), total antioxidant status (TAS), oxidative stress index (OSI), irisin and betatrophin were measured. Results. Serum irisin levels were decreased and TOS and OSI levels were found to be increased in the patient group. No significant difference was found with respect to serum betatrophin and IMA levels between study groups. A correlation analysis revealed no correlation between serum irisin and other assessed variables. Conclusions. Gestational diabetes mellitus is an OS condition in addition to being a metabolic disease. Although not correlated with OS, irisin but not betatrophin may be a useful biomarker to predict GDM.
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Beyazıt et al. (2020) conducted a cross-sectional in Gestational diabetes mellitus (n=90). Gestational diabetes mellitus vs. Normal glucose tolerance was evaluated on Serum irisin levels (μg/mL) (p=0.038). Pregnant women with gestational diabetes mellitus had significantly lower serum irisin levels compared to healthy controls (2.62 vs 3.41 μg/mL, p=0.038), while betatrophin levels did not differ.
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