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Abstract 3,4‐Methylenedioxyphenol (sesamol) condenses with pyrrolidine and aromatic aldehydes to yield Mannich bases of type4. The Mannich bases react readily with ketonic reagents to form pyrrolidinylbenzopyran derivatives which provide a simple route to antimitotic and bioactive heterocyclic analogs of the anti‐cancer drug, podophyllotoxin.
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Leonard Jurd (1988) studied this question.
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