Key result
Optimized LVAD control strategy improves cardiac efficiency and reduces oxygen consumption in physical circuit models.
In vitro testing of an LVAD identified optimal control parameters (driving pressure and timing) to minimize oxygen consumption and maximize mechanical efficiency for heart recovery.
In vitro LVAD optimization is hypothesis-generating; requires animal and clinical validation before any practice consideration.
In this study an original left ventricular assist device is tested on an open loop modular physical circuit reproducing Starling's law of the heart to set an optimal control strategy for heart recovery. It is assumed that the goals of the assistance are reduction of oxygen consumption, external work and improvement of cardiac mechanical efficiency. The assistance is evaluated by the position of a working point on the characteristic surfaces of the ventricle defined by peripheral resistance, atrial pressure and selected variables pertaining to energy (pressure-volume area, external work and cardiac mechanical efficiency). In this frame an optimal assistance for heart recovery is a compromise among different requirements corresponding to a restricted set of control parameters values: driving pressure PZB = 35 kPa and timing values T1 and T2 (systole beginning and systole ending in relation to QRS complex and cardiac cycle duration T) T1 = 0.55.T and T2 = 0.73.T.
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Ferrari et al. (1996) studied Heart recovery. Left ventricular assist device control strategy was evaluated on Reduction of oxygen consumption, external work and improvement of cardiac mechanical efficiency. An optimal control strategy for a left ventricular assist device to improve cardiac mechanical efficiency and reduce oxygen consumption was identified using an open loop modular physical circuit.
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