Timing of percutaneous coronary intervention in patients with non-ST-elevation myocardial infarction: a SWEDEHEART study
Key result
Early PCI within one day is linked to ~12% lower all-cause mortality versus delayed PCI.
- HR 0.88
- 95% CI 0.80-0.98
- n=40,494
Why the study?
Does early PCI reduce all-cause death in patients with NSTEMI compared to delayed PCI?
Population
40,494 consecutive PCI-treated patients with non-ST-elevation myocardial infarction admitted to any coronary…
Comparison
Early percutaneous coronary intervention within… vs Delayed percutaneous coronary intervention…
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Implication
Does not yet support earlier PCI in NSTEMI; leaves open whether RCTs will confirm mortality benefit.
Study Design
Type
Cohort (n=40,494)
Multicenter
Yes
Structured PICO
Does early PCI reduce all-cause death in patients with NSTEMI compared to delayed PCI?
P
Population
40,494 consecutive PCI-treated patients with NSTEMI admitted to Swedish coronary care units, followed for 1 year.
E
Exposure
Early percutaneous coronary intervention (PCI) within 1, 2, or 3 days of admission.
C
Comparator
Delayed percutaneous coronary intervention (PCI) beyond the 1, 2, or 3-day cut-offs.
O
Outcome
All-cause death within 1 year from admission.hard clinical
Main Result
Hazard Ratio: 0.88 (95% CI 0.8–0.98)
In patients with NSTEMI, early PCI (within 1 to 3 days) is associated with a significantly lower risk of all-cause death at 1 year compared to delayed PCI.
Cite This Study
Lindholm et al. (2016) conducted a cohort in Non-ST-elevation myocardial infarction (NSTEMI) (n=40,494). Early PCI (within 1, 2, or 3 days) vs. Delayed PCI was evaluated on All-cause death (HR 0.88, 95% CI 0.80-0.98). Early PCI within 1, 2, or 3 days was associated with a lower risk of all-cause death compared to delayed PCI (HRs 0.88, 0.78, and 0.75, respectively).