Key result
Prazosin fails to reduce intimal thickness in experimental vein grafts versus control at 3 weeks.
Null result in rat vein grafts; leaves open whether prazosin modulates intimal hyperplasia in clinical bypass surgery.
The influence of prazosin on experimental vein graft intimal thickening was studied in a rat model. The iliolumbar vein was grafted into the common iliac artery in a prazosin-treated group (n = 17) and a control group (n = 23). Three weeks after grafting the animals were killed and the grafts harvested. Longitudinal sections were prepared and the intimal thickness measured in the proximal, mid and distal graft. Intimal thickness varied considerably in both groups. Median (range) intimal thicknesses for the control group were: proximal 50 (10-120) microns; mid 30 (10-70) microns; and distal graft 30 (10-100) microns. Results for the prazosin-treated group were: proximal 70 (10-160) microns; mid 25 (5-60) microns; and distal graft 25 (5-135) microns. There was no statistically significant difference in median intimal thicknesses between the control and treated groups.
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Norman et al. (1992) studied Vein graft intimal thickening (n=40). Prazosin vs. Control was evaluated on Median intimal thickness in the proximal, mid, and distal graft. Prazosin treatment did not significantly affect median intimal thickness in experimental vein grafts compared to control at 3 weeks.
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